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Det er fireplace «svake opioider» tilgjengelig i Norge: kodein, tramadol, dekstropropoksyfen og pentazocin. Disse er omtrent like effektive. Alle fire har risiko for avhengighet og misbruk ved behandling som varer utover 2?–?4 uker. Kodein har størst terapeutisk bredde og har minst farlige og minst plagsomme bivirkninger. Mye av kodeinets sme

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